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We have an exciting opportunity for two Bioorganic Chemists to join our GSK Enzyme Engineering and Biocatalysis group based in Stevenage, UK.

As a bioorganic chemist, you will be responsible for supporting our work using novel enzymes variants for the synthesis of nucleic acid APIs with applications across the full GSK portfolio. Working closely with project teams, you would optimise synthetic reaction and isolation processes for complex oligonucleotide products and help support enzyme evolution programs as part of an interdisciplinary team of experts.

The role is fast-paced and dynamic, you will thrive in this environment if you are able to effectively manage multiple priorities, communicate your recommendations clearly and enjoy working in teams.

In this role you will

• Be responsible for a wide range of activities supporting development of synthetic processes for oligonucleotide products.
• Develop cascade and telescoped enzymatic routes to oligonucleotides
• Optimise reaction conditions for efficient production of desired products
• Work with colleagues from process chemistry to develop scalable and manufacturable processes
• Work with engineering colleagues to optimise isolation of oligonucleotide products
• Work with analytical colleagues to optimise characterisation of reaction products and reaction performance
• Design experiments, collecting and analysing data using programs such as MS Excel, TIBCO Spotfire and bespoke software tools to inform decisions
• Interact with partners in discovery, development, and manufacturing to identify and pursue enzyme opportunities
• Generate conclusion reports, presenting data in team meetings & participating in writing of abstracts & publications
• Conduct scientific work programs and making contributions both independently and as a member of a team with other R&D staff
• Maintain customer focus, motivating self, and demonstrating a high degree of urgency
• Exhibit flexibility, being open to new ways of working

Why you?

Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• Bachelor’s degree (or equivalent) in chemistry or a relevant life science
• Practical laboratory experience of the identification of enzymes to perform reactions of interest, and the optimization of those enzymes under synthetically relevant conditions

Preferred Qualifications & Skills:

If you have the following characteristics, it would be a plus:

• Doctoral/PhD degree (or equivalent) in Organic Chemistry, Biochemistry or related discipline OR Master’s degree (or equivalent) and relevant laboratory experience
• Practical laboratory experience with enzymatic synthesis of (oligo-)nucleotides, nucleic acids
• Familiarity with analysis of nucleic acid reactions to characterise kinetics, thermodynamics and reaction performance
• Familiarity with isolation of nucleic acids from reactions
• Demonstrated ability to work in multi-disciplinary teams, displaying excellent interpersonal, organizational, and communication skills

Closing Date for Applications: 23rd April 2023 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

#CMCDevelopmentGSK

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

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We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

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