Using zebrafish models to understand the neuropathology of rare diseases
Leukodystrophies are rare diseases affecting specific areas of the brain called the white matter. This consists mainly of a protective insulating sheath (myelin) surrounding our nerve cells. Over 100 leukodystrophies have been described but due to the rarity of limited research available, there is little understanding of the mechanisms of the pathology and limited treatments are available. As part of the LEUKOLABS network founded by the supervisor and colleagues to bring together clinical and research leukodystrophy experts, we developed multiple zebrafish models for those rare diseases. We have made a model for Krabbe Disease, a particularly devastating leukodystrophy, which will be the main focus of this project. The post holder will analyse the contribution of the immune system to the development of the pathology, using already established imaging assays in the transparent zebrafish. This project is part of a multi-disciplinary team with colleagues working in parallel on iPSC-models in the US.
This is a unique opportunity to develop your research skills in an exciting and clinically relevant environment. Applicants must have experience in laboratory work, and due to the short-term contract, preference will be given to candidates with experience in zebrafish in vivo work and/or molecular biology techniques.
This project is funded by a research grant to Dr Noémie Hamilton (York) from The Legacy of Angels Foundation.
- To provide technical and scientific support to research project in the laboratory. These will focus on zebrafish techniques (microinjection, staining, imaging) and molecular cloning.
- Research, collect and manage data collected in the laboratory for future use in publications and grant applications.
- Maintain accurate records of work undertaken, including reports, using appropriate (bespoke) software.
- Liaise with appropriate staff and external service providers to ensure the work area and equipment are kept operational.
- HNC, HND, Degree or equivalent in appropriate science discipline or appropriate experience
- Relevant theoretical knowledge in Biology
- In depth knowledge of relevant safety regulations and procedures for example, COSHH and risk assessment
- Knowledge and ability to implement practical techniques used in relevant work area
- Evidence of having contributed to activities using a variety of sometimes specialist technical skills
- Experience of Molecular Biology (e.g. PCR, Western Blotting); training in zebrafish work is not assumed and can be provided but will be advantageous
- Experience of working on own initiative and as part of a team
Interview date: 6 July 2023
For informal enquiries: Please contact Dr Noémie Hamilton by email at noemie.hamilton@york.ac.uk
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We particularly encourage applications from people who identify as Black, Asian or from a Minority Ethnic background, who are underrepresented at the University.
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